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When a molecule has fewer electrons than protons, it is oxidized and unstable
The execution of ferroptosis involves complex regulation of multiple metabolic pathways (Figure 1), including disruptions in iron homeostasis, abnormalities in amino acid antioxidant systems, and the accumulation of lipid peroxides (Zheng et al., 2025
The supernatant was aspirated and the cell pellet was suspended in supplemented DMEM media for further experiments
The N-terminal domain is primarily involved in binding glutathione, while the C-terminal domain contributes to the binding of various hydrophobic substrates
10.1016/j.gene.2015.02.011 63 ZhangH.Kovacs-NolanJ.KoderaT.EtoY.MineY
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